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Reaction Biology/Daminozide/EI-DEM-006
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Daminozide
1-(2,2-Dimethylhydrazide)butanedioicacid;N-(dimethylamino)succinamicacid,DaminozideisaselectiveinhibitoroftheKDM2/7JmjCsubfamilyofhistonedemethylases.IC50=1.5,0.55and2.1mMforKDM2A,PHF8andKDM7Arespectively.Highlyselectiveoverothersubfamilymembers(KDM3,KDM4,KDM5andKDM6)aswellasother2-oxoglutarateoxygenases(FIH,PHD2andBBOX1),IC50>100mMPhysicalProperties:Whitepowder;MP=158-162°C
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1-(2,2-Dimethylhydrazide)butanedioicacid;N-(dimethylamino)succinamicacid,DaminozideisaselectiveinhibitoroftheKDM2/7JmjCsubfamilyofhistonedemethylases.IC50=1.5,0.55and2.1mMforKDM2A,PHF8andKDM7Arespectively.Highlyselectiveoverothersubfamilymembers(KDM3,KDM4,KDM5andKDM6)aswellasother2-oxoglutarateoxygenases(FIH,PHD2andBBOX1),IC50>100mMPhysicalProperties:Whitepowder;MP=158-162°CMW=160.2C6H12N2O3
Analysis:98%(TLC);NMR(Conforms)
Solubilization:MaybedissolvedinDMSO(50mg/ml);orwater(20mg/ml,warm)
Storage:Storedesiccatedassuppliedatambienttemperatureforupto3years.Storesolutionsat-20°Cforupto3months.
Amount:50mg我要提问
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