BiologicalActivity
Monocarboxylatetransporter(MCT1)inhibitor(pKi=7.6.Exhibitsapproximately10-foldselectivityforMCT1overMCT2andnosignificantactivityagainstMCT3or4.Inhibitsgraftversushostresponseandprolongscardiacgraftsurvivalinaratmodel.Immunosuppressant.AlsoinhibitsbrainpenetrationofGHBanalogHOCPCA.
TechnicalData
| M.Wt | 529.05 |
| Formula | C26H28N4O4S.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| Smiles | O=C(N1C[C@H](O)CC1)C2=C(CC3=C4C(C=CC=C4)=NC=C3)SC(N5CC(C)C)=C2C(N(C)C5=O)=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.26 | 100 | |
| ethanol | 49.26 | 100 | |
| water | 49.26 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight529.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.89mL | 9.45mL | 18.9mL |
| 5mM | 0.38mL | 1.89mL | 3.78mL |
| 10mM | 0.19mL | 0.95mL | 1.89mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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