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Description:Dualhistonedeacetylase(HDAC)6/8inhibitor
ChemicalName:N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Dualhistonedeacetylase(HDAC)6/8inhibitor.IC50valuesare0.036μM,0.12μM,9μM,>33μM,forHDAC6,HDAC8,HDAC2andHDAC4,respectively.
TechnicalData
| M.Wt | 284.31 |
| Formula | C16H16N2O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1440209-96-0 |
| PubChemID | 71680913 |
| InChIKey | FIHKWEQJEDRIFS-UHFFFAOYSA-N |
| Smiles | ONC(C1=CC=CC(C(NCCC2=CC=CC=C2)=O)=C1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.43 | 100 | |
| ethanol | 5.69 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight284.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.52mL | 17.59mL | 35.17mL |
| 5mM | 0.7mL | 3.52mL | 7.03mL |
| 10mM | 0.35mL | 1.76mL | 3.52mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
