BiologicalActivity
Syntheticprogesteroneanalog.Dose-dependentlyinhibitsgrowthofHepG2cells(IC50=260μM)invitroandinvivoandreducestumorvolume.Highdosagesimproveweightgainintumor-bearingnudemice.Orallybioavailable.
TechnicalData
| M.Wt | 384.51 |
| Formula | C24H32O4 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 595-33-5 |
| PubChemID | 11683 |
| InChIKey | RQZAXGRLVPAYTJ-GQFGMJRRSA-N |
| Smiles | [H][C@@]12CC[C@](C(C)=O)([C@]1(CC[C@]3([C@]2(C=C(C4=CC(CC[C@]34C)=O)C)[H])[H])C)OC(C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.23 | 50 | |
| ethanol | 7.69 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight384.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.6mL | 13mL | 26.01mL |
| 5mM | 0.52mL | 2.6mL | 5.2mL |
| 10mM | 0.26mL | 1.3mL | 2.6mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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