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Description:DR5(TRAILreceptor)agoNIST;inducesapoptosis
ChemicalName:5-[5-[[(5Z)-3-(4-Bromophenyl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]-1H-isoindole-1,3(2H)-dione
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
DR5(TRAILreceptor)agonist.DirectlybindsextracellulardomainofDR5(Kd=1.2μM)andinducestheformationofDR5aggregates.Inducesapoptosisofglioblastomacells.
TechnicalData
| M.Wt | 494.32 |
| Formula | C22H12BrN3O4S |
| Storage | Storeat+4°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 1420071-30-2 |
| PubChemID | 70678419 |
| InChIKey | ULBOWKXOFOTCMU-NLDKGBHCSA-N |
| Smiles | BrC1=CC=C(N3C(/C(SC3=N)=C/C2=CC=C(C4=CC=C(C(NC5=O)=O)C5=C4)O2)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 0.49 | 1mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight494.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.02mL | 10.11mL | 20.23mL |
| 5mM | 0.4mL | 2.02mL | 4.05mL |
| 10mM | 0.2mL | 1.01mL | 2.02mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
MolarityCalculator
MolarityCalculator
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ReconstitutionCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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