MHC II Dextramer DRB1*0401 (IAFTSEHSHFSLK)

Product Code: FB10013

Fluorescent MHC II Dextramers® for sensitive and specific detection of antigen-specific CD4+ T cells using flow cytometry. Available in three colors (PE, APC, and FITC), covering human alleles. Amount: 1 vial containing 50 /150 / 500 or 1000 testsApplication(s): Cellular immune response, Immune monitoring, T-cell assays, ImmunohistochemistryIndication(s)/Topic(s): AIDS, Autoimmune disease, Breast cancer, Cancer, Cancer chemotherapy, Control, Diabetes, Graft-vs-host disease, Hematopoetic system, Hepatitis, Infection, Malaria, Malignant genital cancers, Melanoma, Prostate cancer, Testis/ovary cancer, Tuberculosis, Transplantation, Vaccination, Wilms tumor 1Delivery Time: 10-12 days

MHC II Dextramers® MHC Multimers such as Dextramers® are used for detection, enumeration and isolation of antigen-specific T cells in fluid cell samples (PBMC, blood) by flow cytometry, and can be applied to tissue sections to visualize antigen-specific T cells in situ.Fields of application are vaccine and immunotherapeutic development, clinical trials, immune monitoring of transplantation patients, patients with HIV and many more. The MHC class II Dextramers® combine a dextran polymer backbone with a high number of MHC and fluorochrome molecules. This enhances their staining intensity, thereby increasing resolution and the signal-to-noise ratio with minimal background staining. In addition, the polymer backbone stabilizes the MHC-peptide complexes and fluorochromes.

Benefits of MHC II Dextramers®- More MHC molecules and more fluorochromes than conventional MHC multimers (e.g. tetramers)- Higher sensitivity (important for low affinity epitopes as commonly found in cancer & autoimmune disease)- Very stable- Custom-made Dextramers® available upon request