BiologicalActivity
Highaffinityantagonistofthereceptorforadvancedglycationendproducts(RAGE)(Ki=25nM).BlocksAβbindingtotheVdomainofRAGEandinhibitsAβ40-andAβ42-inducedcellularstressinRAGE-expressingcellsinvitroandinthemousebraininvivo.Blocksβ-secretaseactivity,Aβproduction,microgliaactivationandneuroinflammationinvivo.BBBpermeable.
TechnicalData
| M.Wt | 327.85 |
| Formula | C20H22ClNO |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 945714-67-0 |
| PubChemID | 24752728 |
| InChIKey | XDFKWGIBQMHSOH-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.78 | 100 | |
| ethanol | 32.78 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight327.85.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.05mL | 15.25mL | 30.5mL |
| 5mM | 0.61mL | 3.05mL | 6.1mL |
| 10mM | 0.31mL | 1.53mL | 3.05mL |
| 50mM | 0.06mL | 0.31mL | 0.61mL |
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