BiologicalActivity
PotentC5areceptorantagonist(IC50=20nM).AlsoMrgX2agonist.StimulatesMrgX2-mediatedmastcelldegranulation.AlsoinhibitsC5a-inducedhypernociceptioninrats,inhibitslungmetastasisinamousebreastcancermodelandreducesatheroscleroticlesionsinamousemodelofatherosclerosis.
TechnicalData
| M.Wt | 896.1 |
| Formula | C47H65N11O7 |
| Sequence | FXPXWR (Modifications:Phe-1=N-terminalAc,X-2=Orn,X-4=D-Cha,Lactambridge:Orn-2toArg-6) |
| Storage | Storeat-20°C |
| CASNumber | 219639-75-5 |
| PubChemID | 23526550 |
| InChIKey | YOKBGCTZYPOSQM-UHFFFAOYSA-N |
| Smiles | NC(=NCCCC1NC(=O)C(NC(=O)C(CC2CCCCC2)NC(=O)C2N(C(=O)C(CCCNC1=O)NC(=O)C(Cc1ccccc1)NC(=O)C)CCC2)Cc1c[nH]c2c1cccc2)N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto2mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight896.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.12mL | 5.58mL | 11.16mL |
| 5mM | 0.22mL | 1.12mL | 2.23mL |
| 10mM | 0.11mL | 0.56mL | 1.12mL |
| 50mM | 0.02mL | 0.11mL | 0.22mL |
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