BiologicalActivity
Mitochondrialelectrontransportchaininhibitor(IC50=1.7-2.2μMatcomplexI).InhibitsNADHoxidationbycardiacsarcoplasmicreticulum(IC50=3.4nM).CommonlyusedpesticideandinducesParkinsonisminanimalmodels.Mayalsoinhibitautophagyinduction;blockslysosomaldegradationofautophagicvacuoles.Cell-permeableandbrainpenetrant.
TechnicalData
| M.Wt | 394.42 |
| Formula | C23H22O6 |
| Storage | StoreatRT |
| Purity | ≥95%(HPLC) |
| CASNumber | 83-79-4 |
| PubChemID | 6758 |
| InChIKey | JUVIOZPCNVVQFO-HBGVWJBISA-N |
| Smiles | C=[C@](C)[C@@H](C5)OC4=C5C(O3)=C(C=C4)C([C@@]([C@@]3([H])CO2)([H])C1=C2C=C(OC)C(OC)=C1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.44 | 100 | |
| ethanol | 1.97 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight394.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.54mL | 12.68mL | 25.35mL |
| 5mM | 0.51mL | 2.54mL | 5.07mL |
| 10mM | 0.25mL | 1.27mL | 2.54mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
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