BiologicalActivity
PositiveregulatorofautophagyinamechanismindependentfromthemTORpathway.IncreasesautophagosomesynthesisandenhancesclearanceofmodelautophagysubstratessuchasmutanthuntingtinandA53Tα-synuclein,associatedwithHuntington'sandParkinson'sdiseases,respectively.Promotesreprogrammingoffibroblaststoneuralstem-likecellsincombinationwithotherchemicalreagents.
CompoundLibraries
SMER28isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 264.12 |
| Formula | C11H10BrN3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 307538-42-7 |
| PubChemID | 1560402 |
| InChIKey | BCPOLXUSCUFDGE-UHFFFAOYSA-N |
| Smiles | C=CCNC2=NC=NC1=CC=C(Br)C=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| ethanol(suppliedpre-dissolvedinabsoluteethanol,27µg/ml) | 13.21 | 50 | |
| DMSO | 26.41 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight264.12.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.79mL | 18.93mL | 37.86mL |
| 5mM | 0.76mL | 3.79mL | 7.57mL |
| 10mM | 0.38mL | 1.89mL | 3.79mL |
| 50mM | 0.08mL | 0.38mL | 0.76mL |
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