BiologicalActivity
Potentα2β1integrininhibitor(IC50valuesfortheinhibitionofhumanplateletadhesiontotypeIcollagenare12and715nMforplateletsunderstaticconditionsandunderflow,respectively).Displaysselectivityforα2β1overαvβ3,α5β1,α6β1andαIIbβ3atconcentrationsexceeding1000nM.ReducescollagenIVproductioninmesangialcells.Activeinvivo;preventsferricchloride-inducedclotformationinmice.
LicensingInformation
SoldunderlicensefromtheUniversityofPennsylvania.
CompoundLibraries
TC-I15isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 520.62 |
| Formula | C23H28N4O6S2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 916734-43-5 |
| PubChemID | 90488948 |
| InChIKey | XKLHCUGVLCGKKX-RBUKOAKNSA-N |
| Smiles | CC1(C)SCN(S(C3=CC=CC=C3)(=O)=O)[C@@H]1[C@@](N[C@H](C(O)=O)CNC(NCC2=CC=CC=C2)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq.NaOH | 13.02 | 25 | |
| DMSO | 52.06 | 100 | |
| ethanol | 52.06 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight520.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.92mL | 9.6mL | 19.21mL |
| 5mM | 0.38mL | 1.92mL | 3.84mL |
| 10mM | 0.19mL | 0.96mL | 1.92mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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