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Description:α4β1(VLA-4)antagoNIST
ChemicalName:1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediaceticacid
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Integrinverylateantigen-4(VLA-4;α4β1)antagonist(IC50=4.4nM).Blockstheactivationofinflammatorycells.
CompoundLibraries
TCS2314isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 522.59 |
| Formula | C28H34N4O6 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 317353-73-4 |
| PubChemID | 11226207 |
| InChIKey | ITXAAOWFOURIHK-DEOSSOPVSA-N |
| Smiles | O=C(N2CCOC[C@H]2[C@@](N3CCC(CC(O)=O)CC3)=O)CC1=CC=C(NC(NC4=C(C)C=CC=C4)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.26 | 100 | |
| ethanol | 26.13 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight522.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.91mL | 9.57mL | 19.14mL |
| 5mM | 0.38mL | 1.91mL | 3.83mL |
| 10mM | 0.19mL | 0.96mL | 1.91mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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