BiologicalActivity
Aquaporin4(AQP4)channelblocker(IC50=3.1μM).Increasesregionalcerebralbloodflowandreducesischemia-inducedbrainedemainmice.
TechnicalData
| M.Wt | 206.22 |
| Formula | C8H6N4OS |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 51987-99-6 |
| PubChemID | 4173511 |
| InChIKey | AGEGZHOPKZFKBP-UHFFFAOYSA-N |
| Smiles | O=C(NC1=NN=CS1)C2=CN=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 2.06 | 10mMwithgentlewarming | |
| DMSO | 4.12 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight206.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.85mL | 24.25mL | 48.49mL |
| 5mM | 0.97mL | 4.85mL | 9.7mL |
| 10mM | 0.48mL | 2.42mL | 4.85mL |
| 50mM | 0.1mL | 0.48mL | 0.97mL |
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