BiologicalActivity
Anticancerandimmunosuppressiveagentoftenusedtotreatimmunedisordersandleukemia.Displayscytotoxicandantineoplasticproperties;disruptscytosinemethylationbyDNAmethyltransferasesafterincorporationintoDNA.SelectivelykillsBRCA2-defectivetumorsinaxenograftmodel.Alsofacilitatesproteasome-mediateddegradationofDNA(cytosine-5)-methyltransferase1(DNMT1).
TechnicalData
| M.Wt | 167.19 |
| Formula | C5H5N5S |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 154-42-7 |
| PubChemID | 2723601 |
| InChIKey | WYWHKKSPHMUBEB-UHFFFAOYSA-N |
| Smiles | NC1=NC(S)=C2C(NC=N2)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.72 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight167.19.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.98mL | 29.91mL | 59.81mL |
| 5mM | 1.2mL | 5.98mL | 11.96mL |
| 10mM | 0.6mL | 2.99mL | 5.98mL |
| 50mM | 0.12mL | 0.6mL | 1.2mL |
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