Tocris小分子 Tocris配体,Tocris/Vinorelbine ditartrate/3401/10/10 mg,其他试剂,其他,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/Vinorelbine ditartrate/3401/10/10 mg

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Tocris/Vinorelbine ditartrate/3401/10/10 mg

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Tocris

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3401/10

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4000-520-616

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Description:SelectivemitoticmicrotubuleantagoNIST

AlternativeNames:Navelbine

ChemicalName:(2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylicacidmethylester

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectivemitoticmicrotubuleantagonistthatexhibits>20foldselectivityoveraxonalmicrotubules.Inhibitsproliferationofmultiplehumantumorcelllines(IC₅₀=1.25nMinHeLacells)andblocksmetaphase/anaphasetransitionbysuppressionofmicrotubuledynamics(IC₅₀=3.8nM).Reducesspindlelengthby29%andinhibitsmicrotubulepolymerizationatmicromolarconcentrations.

TechnicalData

M.Wt	1079.1
Formula	C₄₅H₅₄N₄O₈.2C₄H₆O₆
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	125317-39-7
PubChemID	5311497
InChIKey	GBABOYUKABKIAF-IELIFDKJSA-N
Smiles	[H][C@@]23N(C)C1=CC(OC)=[C@]([C@@](C7=C(C9)C(C=CC=C8)=C8N7)([C@](OC)=O)C[C@]6([H])C=C(CC)CN9C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O.O=C(O)C(O)C(O)C(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	107.91	100
	water	107.91	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight1079.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.93mL	4.63mL	9.27mL
5mM	0.19mL	0.93mL	1.85mL
10mM	0.09mL	0.46mL	0.93mL
50mM	0.02mL	0.09mL	0.19mL

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BiologicalActivity

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