| Serum-SalivaCorrelation | 0.77 |
| Sensitivity | 5pg/mL |
| SampleTestVolume | 50μL |
| RecommendedCollectionVolume | 125μL* |
| SpecialConsiderations | No |
| CollectionProtocol | DownloadPDF |
Androstenedione(4-androstenedione;4-dione;4-androstene-3,17-dione)isasteroid hormone producedinthe adrenalglands andthe gonads.(1,2,3)ItissynthesizedfromDHEAor17OH-progesterone,anditservesprincipallyastheimmediateprecursorcompoundthatisconvertedintotestosteroneorestrone,bothofwhichmaythenbefurtherconvertedintoestrADIol.(4) ThesamesequenceofconversionofDHEAandandrostenedioneintoothersteroidsalsotakesplaceinmanyperipheraltissuesthroughoutthebody,allowingandrogensandestrogenstobedeliveredtotheappropriatetissueswithoutleakageofsignificantamountsintothecirculation.(5,6)Levelsofandrostenedionebegintoincreaseinchildrenataboutage6-8,anditservesasthemainsourceofandrogenspriortogonadarche. (7) Highlevelsofandrostenedionemayconferandrogenicrisk,especiallyinfemales,andestrogenicrisks,especiallyinmales.Childrenandadolescentsareparticularlyvulnerabletotheeffectsofandrostenedioneconversiontoactivesexsteroids.
Theseeffectsmaydisruptnormalsexualdevelopment,specificallyvirilizationingirlsassociatedwithsevereacne,excessivebodyhair,disruptionofthemenstrualcycle,andinfertility.Theconversionofandrostenedionetoestrogenscancausefeminizationofboys.(8,9) Elevatedlevelshavebeenassociatedwithdisruptivebehaviordisordersinchildren.(7) MeasurementofserumandrostenedioneisusedasaMarkerofandrogenbiosynthesis. Highcirculatingandrostenedionelevelsareindicatedinvirilizingcongenitaladrenalhyperplasia,polycysticovariansyndrome,andothercausesofhirsutisminwomen. Elevatedandrostenedionelevelsmayalsooccurasaresultofadrenalorovariantumors.(10,11) Androstenedioneexhibitsadiurnalrhythmsimilartothatofcortisol,withhighestlevelsinthemorningandanadirinthelateevening.(12,13)
Inblood,androstenedioneisnotstronglyboundtosexhormonebindingglobulin(SHBG)oralbumin. Approximately95%ofcirculatingandrostenedioneisavailabletotissues.(14) Unboundandrostenedioneenterssalivafrombloodviaintracellularmechanisms,andthecorrelationbetweenserumandsalivavaluesishighlysignificant.(15)
- Yates,J.,Deshpande,N.(1974). Kineticstudiesontheenzymescatalyzingtheconversionof17α-hydroxy-progesteroneanddehydroepiandrosteronetoandrostenedioneinthehumanadrenalglandinvitro.JEndocrinol,6(1),27-35.
- Carson,R.S.,Findlay,J.K.,Clarke,I.J.,Burger,H.G.(1981). Estradiol,testosterone,andandrostenedioneinovinefollicularfluidduringgrowthandatresiaofovarianfollicles. BiolReprod,24(1),105-113.
- Weinstein,R.L.,Kelch,R.P.,Jenner,M.R.,etal.(1974).Secretionofunconjugatedandrogensandestrogensbythenormalandabnormalhumantestisbeforeandafterhumanchorionicgonadotropin. JClinInvest,53(1),1-6.
- Dorfman,R.I.,Shipley,R.A.(1956).Androgens.NewYork:JohnWileyandSons.
- Labrie,F.,Bélanger,A.,Cusan,L.,Candas,B.(1997). Physiologicalchangesindehydroepiandrosteronearenotreflectedbyserumlevelsofactiveandrogensandestrogensbutoftheirmetabolites:Intracrinology. JClinEndocrinolMetab,82(8),2403-9.
- Labrie,F.,Luu-The,V.Bélanger,A.,etal.(2005). Isdehydroepiandrosteroneahormone?JEndocrinol,187(2),169-96.
- Dorn,L.D.,Kolko,D.J.,Susman,E.J.,etal.(2009). Salivarygonadalandadrenalhormonedifferencesinboysandgirlswithandwithoutdisruptivebehaviordisorders:Contextualvariants. BiolPsychol,81(1),31-39.
- King,D.S.,Sharp,R.L.,Vukovich,M.D.,etal.(1999). Effectoforalandrostenedioneonserumtestosteroneandadaptationstoresistancetraininginyoungmen:Arandomizedcontrolledtrial.JAMA,281(21),2020-8.
- Leder,B.Z.,Longcope,C.,Catlin,D.H.,etal.(2000). OralandrostenedioneadmiNISTrationandserumtestosteroneconcentrationsinyoungmen. JAMA,283(6),779-82.
- Leder,B.Z.,Leblanc,K.M.,Longcope,C.,etal.(2002). Effectsoforalandrostenedioneadministrationonserumtestosteroneandestradiollevelsinpostmenopausalwomen. JClinEndocrinolMetab,87(12),5449-54.
- Kicman,A.T.,Bassindale,T.,Cowan,D.A.,etal.(2003). Effectofandrostenedioneingestiononplasmatestosteroneinyoungwomen;Adietarysupplementwithpotentialhealthrisks.ClinChem,49(1),167-9.
- Goldman,J.,Wajchenberg,B.L.,Liberman,B.etal.(1985). Contrastanalysisfortheevaluationofthecircadianrhythmsofplasmacortisol,androstenedione,andtestosteroneinnormalmenandthepossIBLeinfluenceofmeals. JClinEndocrinolMetab,60(1),164-67.
- Ostrowska,Z.Zwirska-Korczala,K.,Pardela,M.,etal.(1998). Circadianvariationsofandrostenedione,dehydroepiandrosteronesulfateandfreetestosteroneinobesewomenwithmenstrualdisturbances.EndocrRegul,32(4),169-76.
- Longcope, C.,Baler, S.(1993). Androgenandestrogendynamics:Relationshipswithage,weight,andmenopausestatus.JClinEndocrinolMetab,76(3),601–4.
- Vining,R.F.,McGinley,R.A.(1987).Themeasurementofhormonesinsaliva:Possibilitiesandpitfalls. JSteroidBiochem,27(1-3),81-94.
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（1）优级纯试剂 亦称保证试剂，为一级品，纯度高，杂质极少，主要用于精密分析和科学研究，常以GR表示。
（2）分析纯试剂 亦称分析试剂，为二级品，纯度略低于优级纯，杂质含量略高于优级纯，适用于重要分析和一般性研究工作，常以AR表示。
（3）化学纯试剂 为三级品，纯度较分析纯差，但高于实验试剂，适用于工厂、学校一般性的分析工作，常以CP表示。
（4）实验试剂 为四级品，纯度比化学纯差，但比工业品纯度高，主要用于一般化学实验，不能用于分析工作，常以 LR表示。
以上按试剂纯度的分类法已在我国通用。根据化学工业部颁布的“化学试剂包装及标志”的规定，化学试剂的不同等级分别用各种不同的颜色来标志，见表1。
表1 我国化学试剂的等级及标志
bhclna2so4nano3na2co3
chclnaohna2co3nacl
dba(oh)2nahco3alcl3nahso4
刚入这行，谢谢大家
A.H2SO4Na2SO4AgNO3BaCl2.
B.NaOHNa2CO3NaHSO4MgCl2
C.CaCl2NaNO3MgSO4BaCl2
D.HNO3KOHKClK2CO3
暂无品牌分类
