| Product Name | SensoLyte ® 390 Renin Assay Kit*Fluorimetric* |
| Size | 1 kit |
| Catalog # | AS-72039 |
| US$ | $550 |
Renin, a highly specific aspartyl protease, cleaves angiotensinogen, to yield angiotensin I, which is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme).Angiotensin II constricts blood vessels leading to increased blood pressure.It also increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex. Since an overactive renin-angiotensin system leads to hypertension, renin is an attractive target for the treatment of this disease. The SensoLyte® 390 Renin Assay Kit provides a convenient assay for high throughput screening of renin inhibitors and for continuous assay of renin activity using a Mc-Ala/Dnp fluorescence resonance energy transfer (FRET) peptide. In the FRET peptide the fluorescence of Mc-Ala is quenched by Dnp. Upon cleavage into two separate fragments by renin, the fluorescence of Mc-Ala is recovered, and can be monitored at excitation/emission = 330/390 nm. This assay is about four fold more sensitive than an EDANS/DABCYL-based assay and can detect 8 ng/ml of renin. The kit contains: Mc-Ala/Dnp-based FRET peptide substrate (Ex/Em=330/390 nm upon cleavage) Assay buffer Human recombinant renin Renin inhibitor Fluorescence reference standard for calibration A detailed protocol 100 assays (96-well plate) | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) Poster |
| Storage | -20°C |
| Product Citations | Maeda, Y. et al. (2010). Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters. AJP Renal Physiol 299, F1328. |
ebiomall.com
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提醒大家几点：中检所和各地药检所售的都是药典或国家标准中应使用到的标准品和对照品，如果您是建立新药或某些新方法所用到的对照品，他们哪儿一般不会有，此时多为各研究单位自行制备对照品。
在您打电话询问时可以登入中检所的网站在搜索模块中下拉标准物质搜索，看看中检所是否已有此种物质。
若为地方升国标的标准中用到的对照品，中检所一般较少有，最好的方法是找到原始地方标准所在地，与该地的省所联系购买。
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中检所：010－6705152467017755转219/239
北京所：010－66125040
:)河北所：0311－6673174
:)四川所：028－87525503
:)广东所：020-81847931
http://www.gdyjs.org.cn/wxyd/jj.htm
海南所：0898－66222646、66219706、66219772、66218770
http://www.hnyjs.org
:)江苏所：025-83203019852913198663952286631803
http://www.jsidc.org/zxfw/cpzs1.asp
浙江所：0571-8645317186457786
中药标准品：
http://xiehegroup.cn/public_html/page/zjxh_xhqx_zykfzxml.htm
http://www.cctyi.com
http://www.chem911.com/htmls/urls/standard.asp
进口试剂：
http://www.jkchemical.com/home.htm（该公司可以提供USP/BP/JP的对照品）
http://218.30.124.40/
将不定期更新
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广东药检所2003年的对照品一览表，可下载查询：
呵呵，kunben兄我修改一下标题！看看大家效果！
2003年标准品一览表.zip(59.72k)
Blood lipid Standards
