BiologicalActivity
Nrf2activator;activatesNrf,whichbindstoantioxidantresponseelements(AREs)andinducesPhase-Iand-IIdrug-metabolizingenzymesincludingCYP2BandNQO1.AlsoincreasesmRNAlevelsofmultiplehepaticxenobiotictransporters.Elevatesexpressionofgenesencodinganti-oxidantandmultidrugresistance-associatedproteins.Displayschemopreventiveactivity.
TechnicalData
| M.Wt | 226.34 |
| Formula | C8H6N2S3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 64224-21-1 |
| PubChemID | 47318 |
| InChIKey | CKNAQFVBEHDJQV-UHFFFAOYSA-N |
| Smiles | CC1=C(SSC1=S)C2=CN=CC=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.32 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight226.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.42mL | 22.09mL | 44.18mL |
| 5mM | 0.88mL | 4.42mL | 8.84mL |
| 10mM | 0.44mL | 2.21mL | 4.42mL |
| 50mM | 0.09mL | 0.44mL | 0.88mL |
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