
Antibodies to human CD17 react with lactosylceramide which is expressed on granulocytes, monocytes, platelets, and basophils (1). CD17 expression is downmodulated on activated granulocytes. CD17 is an important componant in CD11b/CD18 mediated phagocytosis of microbes (2).
Isotype: Murine IgM
Immunogen: Human beta-2 microglobulin associated proteins from a detergent lysate of PBL
Specificity: Antibody Huly-m13 requires CD17 on human myeloid cells. It does not recognize mouse LacCer (6).
References:
1. Leukocyte Typing IV (W Knapp, et al, eds.) Oxford University Press, Oxford (1989) p. 877-879.
2. Nakayama H, K Iwabuchi, et al. (2008) J Leukocyte Biol 83:728-741.
3. Rusciani A, Duca L, Sartelet H, Chatron-Colliet A, Bobichon H, et al. (2010)PLoS ONE 5(11): e14010.
4. Chatterjee S, Alsaeedi N, Hou J, Bandaru VVR, Wu L, et al. (2013) PLoS ONE 8(5): e63726.
5. Hulkova H, M Elleder, et al. (2005) Virchows Archiv 447(1): 31-44.
6. K Iwabuchi, K Takamori, et al. (2015) Glycobiology 25(6): 655-68. PMID: 25595946
7. H Nakamura, T Murayama, et al. (2017) J cell Biol 118(12): 4370-4382. PMID:2844490DOI:10.1002/jcb.26091
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有机的是有机化合物的简称,它指的是含碳化合物.
但是,有四大类常见物质一般不作为有机物处理:
1、碳的氧化物,如CO和CO2.
2、碳酸及其盐,如CaCO3.
3、金属碳化物,如CaC2.
4、拟卤素及其化合物,如(CN)2与KSCN.
水的化学式为H2O,它不含有碳元素,故不是有机物.
但若所描述的水不是化学意义的水,而是自然界存在的天然水,那么,水中会溶有一定量的有机物.
求助大家,小分子药物最新专利申请情况跟踪,之前听别人说可以在一个网站可以导出这个信息。
不知哪位大侠知道,告知一下,不胜感激!

