Recombinant Human Tau 410 (2N3R) Protein, CF Summary
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins.Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration.The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard.In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
SP-502
| Formulation | 2.2 mg/ml (50μM) in PBS pH 7.4 |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Reconstitution Calculator
Background: Tau
Tau is a microtubule-associated protein expressed primarily in neurons. Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane. Abnormal Tau phosphorylationmay result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer"s disease and other neurodegenerative diseases. Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death. There are multiple forms of Tau--this410 amino acid isoform is known as "2N3R," "Isoform Tau-C,""Tau-3" or "Tau 410" and is referenced in UniProt as P10636-5. This recombinant protein is untagged.
- Billingsley M.L. & Kincaid R.L.(1997) Biochem. J. 323:577
- Bloom G.S. (2014) JAMA Neurol. 71: 505
- Cripps D. et al.(2006) J. Biol. Chem. 281: 10825
- Harada A. et al (1994) Nature 369: 488
- Lei P. et al. (2010) Int. J. Biochem. Cell Biol. 42: 1775
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求助各位前辈，我最近在合成的化合物水溶性很好，非常好，以至于可以随便溶解在水里，它的六氟磷酸盐也可以随意溶解在水里（大于50uM），细胞成像实验显示它根本进不去细胞，求问有没有啥方法包裹一下让它进去？我搜了一下文献，感觉多数是把脂溶性特别好的东西包裹一下弄进去的，也许是搜索姿势不对没找到我需要的答案，**点拨啊！！！
求助各位大神，现在想购买小分子数据库，求大神推荐。
我知道的免费的数据库有zinc
求推荐哪家公司或者研究所的小分子数据库可以购买，十分感谢！！！！！！
求助大家，小分子药物最新专利申请情况跟踪，之前听别人说可以在一个网站可以导出这个信息。
不知哪位大侠知道，告知一下，不胜感激！
就是蛋白质分子的小片断
是氨基酸形成的
一、首先你要明白肽是什么...........................肽是氨基酸通过酰胺键结合而成的东西.........
二、你要明白氨基酸是什么..........................氨基酸是构成蛋白质的基本单位，多种氨基酸结合为长肽链，几条长肽链再盘旋就形成了蛋白质......................
三、关于小分子肽、短肽、多肽、寡肽.......其实都是肽.......区别只是由多少个氨基酸构成而已............
所以，你的问题可以很粗暴地理解为“蛋白质对人体有没有副作用”.......
如果你营养足够的情况下，再补充这个，会导致营养过剩，从而加重身体代谢的负荷............类似就是这样子的了...........小分子肽，一般现在用于化妆品上比较多（一ye子.植物肽面膜就是这个）.......小分子肽（可以简单理解为纳米胶原蛋白），这比蛋白质（也可以粗暴理解为胶原蛋白）更加容易吸收......而用在食品上，要视乎是何种小分子肽了.....大豆肽、花生肽、大米肽....不同的肽有不同的功效.......主要可以改善风味、改善吸收、增强胃肠道功能等等.......
有机的是有机化合物的简称,它指的是含碳化合物.
但是,有四大类常见物质一般不作为有机物处理：
1、碳的氧化物,如CO和CO2.
2、碳酸及其盐,如CaCO3.
3、金属碳化物,如CaC2.
4、拟卤素及其化合物,如(CN)2与KSCN.
水的化学式为H2O,它不含有碳元素,故不是有机物.
但若所描述的水不是化学意义的水,而是自然界存在的天然水,那么,水中会溶有一定量的有机物.
