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Tocris/UCPH 101/3490/10/10 mg

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Tocris

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3490/10

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4000-520-616

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Description:Selectivenon-substrateEAAT1inhibitor

ChemicalName:2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectivenon-substrateinhibitorofEAAT1(IC₅₀valuesare660,>300000and>300000nMforEAAT1,EAAT2andEAAT3respectively).AlsodemonstratesnosignificantinhibitionatEAAT4orEAAT5inapatch-clampelectrophysiologyassay(atfinalconcentrationupto10μM).

TechnicalData

M.Wt	422.48
Formula	C₂₇H₂₂N₂O₃
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1118460-77-7
PubChemID	25223366
InChIKey	YBMGNDPBARCLFT-UHFFFAOYSA-N
Smiles	NC2=C(C#N)C(C3=CC=C(OC)C=C3)C1=C(O2)CC(C4=C(C=CC=C5)C5=CC=C4)CC1=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	10.56	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight422.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.37mL	11.83mL	23.67mL
5mM	0.47mL	2.37mL	4.73mL
10mM	0.24mL	1.18mL	2.37mL
50mM	0.05mL	0.24mL	0.47mL

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