ABCA1基因位于9q31,1，约149kb，其编码一种含有2261个氨基酸的跨膜蛋白，主要参与胆固醇逆转运，即HDL将外周组织过多的胆固醇转运到肝脏的代谢过程。ABCA1将细胞内胆固醇和磷脂转运至细胞表面的HDL前体aooA1，该蛋白负责胆固醇逆转运的第一步也是主要的限速步骤，因此在胆固醇和血浆脂代谢中起着重要的作用。ABCG5和ABCG8是近年被发现的参与植物固醇和胆固醇吸收的基因，与β-谷固醇血症有关，这对基因定位在染色体2p21上，仅相距374个氨基酸，两者都含有13个外显子和12个内含子，分别编码sterolin-1和sterolin-2蛋白，它们在肝脏的肝细胞、胆管细胞、小肠上皮细胞以及胆囊上皮细胞中表达。
Novus提供大量与ABC转运体研究相关的产品，为广大科研用户提供方便。
Catalog# | Product | Host | Type | Application | Species | Ref. |
NB400-105 | ABCA1 | Rabbit | Polyclonal | WB,FACS,ICC,IF,IHC-P,IP | Hu,Mu,Rt,Ha | 132 |
NB400-164 | ABCA1 | Rat | Monoclonal | WB | ||
NB400-165 | ABCA1 | Rat | Monoclonal | FACS | ||
NB100-2068 | ABCA1 | Mouse | Monoclonal | WB,IHC-P | Hu,Mu,Rt | 5 |
NB400-166 | ABCA7 | Rat | Monoclonal | WB,FACS | Mu | |
NB400-163 | ABCA7 | Rat | Monoclonal | WB,FACS | Mu | |
NBP1-77687 | ABCB5 | Rabbit | Monoclonal | ICC,IF,IHC-P | Hu,Mu | |
NB400-116 | ABCE1 | Rabbit | Polyclonal | WB,IP,ICC,IF | Hu | 1 |
NB400-132 | ABCG1 | Rabbit | Polyclonal | WB,ICC,IF,IHC-P | Hu,Mu | 42 |
NB400-117 | ABCG8 | Mouse | Monoclonal | WB | Hu,Mu | 1 |
NB400-110 | ABCG8 | Rabbit | Polyclonal | WB | Hu | 2 |
NBP1-71706 | ABCG8 | Mouse | Monoclonal | WB,IF,IHC-P,IP | Mu | 4 |
NB110-41576 | Abhd5 | Rabbit | Polyclonal | WB | Hu | 3 |
| Catalog：NB400-105 Product:ABCA1Antibody Species:Hu,Mu,Rt,Ha Applications:WB,FACS,ICC,IF,IHC-P,IP |  |
| Catalog：NBP1-77687 Product:ABCB5Antibody Species:Hu,Mu Applications:ICC,IF,IHC-P |  |
| Catalog：NB400-132 Product:ABCG1Antibody Species:Hu,Mu Applications:WB,ICC,IF,IHC-P |  |
产品引用文献：
1.[ABCA1AntibodyNB400-105]McIntoshAL,AtshavesBP,StoreySM,etal.Lossofliverfattyacidbindingproteinsignificantlyaltershepatocyteplasmamembranemicrodomains.JournalofLipidResearch.2012Jan5.[PMID:22223861]
2.[ABCA1AntibodyNB400-105]StoreySM,McIntoshAL,HuangH,etal.IntracellularCholesterolBindingProteinsEnhanceHDL-mediatedCholesterolUptakeinCulturedPrimaryMouseHepatocytes.AmericanJournalofPhysiology.GastrointestinalandLiverPhysiology.2012Jan12.[PMID:22241858]
3.[ABCA1(HJ1)AntibodyNB100-2068]deSouzaPintoR,CastilhoG,PaimBA,etal.InhibitionofMacrophageOxidativeStressPreventstheReductionofABCA-1TransporterInducedbyAdvancedGlycatedAlbumin.Lipids.2012Jan21.[PMID:22271422]
4.[ABCG1AntibodyNB400-132]AyaoriM,YakushijiE,OguraM,NakayaK,HisadaT,Uto-KondoH,TakiguchiS,TeraoY,SasakiM,KomatsuT,IizukaM,YogoM,UeharaY,KagechikaH,NakanishiT,IkewakiK.RetinoicacidreceptoragoNISTsregulateexpressionofATP-bindingcassettetransporterG1inmacrophages.BiochimBiophysActa.2012Feb14;1821(4):561-572.[PMID:22353356]
5.[ABCG8(1B10A5)AntibodyNBP1-71706]WangJ,GrishinN,KinchL,CohenJC,HobbsHH,XieXS.Sequencesinthenonconsensusnucleotide-bindingdomainofABCG5/ABCG8requiredforsteroltransport.JBiolChem.2011Mar4;286(9):7308-14.[PMID:14504269]
6.[Abhd5AntibodyNB110-41576]TimmersS,deVogel-vandenBoschJ,HesselinkM,etal.ParadoxicalIncreaseinTAGandDAGContentParalleltheInsulinSensitizingEffectofUnilateralDGAT1OverexpressioninRatSkeletalMuscle.PLoSONE2011,6(1).[PMID:21264296]
联科生物代理截止时间：2017年6月30日
