BiologicalActivity
KV4channelblocker.BlocksA-typeK+current(ISA)inmousecerebellargranuleneurons.Theaccessorydipeptidylpeptidase-likeproteins(DPP)6and10arerequiredforblockade.
TechnicalData
| M.Wt | 3822.47 |
| Formula | C158H262N50O48S6 |
| Sequence | XIETNKKCQGGSCASVCRKVIGVAAGKCINGRCVCYP (Modifications:X=Glp,Disulfidebridge:8-28,13-33,17-35) |
| Storage | Storeat-20°C |
| PubChemID | 121513877 |
| InChIKey | SVJLXERVUUOWID-UHFFFAOYSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC2=O)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(O)=O)C(C)C)[C@@H](C)CC)C(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight3822.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.26mL | 1.31mL | 2.62mL |
| 5mM | 0.05mL | 0.26mL | 0.52mL |
| 10mM | 0.03mL | 0.13mL | 0.26mL |
| 50mM | 0.01mL | 0.03mL | 0.05mL |
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