TheHER4/erbB4receptortyrosinekinaseisamemberoftheEGF1receptorfamily.HER4isareceptorfortheneuregulins(NRGs),afamilyofgrowthanddifferentiationfactors.HER4canalsobindandbeactivatedbyheparin-bindingEGFgrowthfactor,betacellulin,andepiregulin,membersoftheEGFfamilywhich,unliketheNRGs,arealsoligandsfortheEGFreceptor.HER4mRNAisexpressedinseveraltissuessuchasheart,brain,kidney,andskeletalmuscle,suggestingthatthisreceptorisinvolvedinthedevelopmentandmaintenanceofavarietyoforgansandcelltypes.ItislikelythatthecontrolofexpressionandfunctionofHER4isimportantinnormaldevelopmentaswellasindisease. Contributor: REFERENCES:Ni,C.-Y.,Murphy,M.P.,Golde,T.E.,Carpenter,G.(2001).gamma-SecretaseCleavageandNuclearLocalizationofErbB-4ReceptorTyrosineKinase.Science294:2179-2181RioC,BuxbaumJD,PeschonJJ,CorfasG.Tumornecrosisfactor-alpha-convertingenzymeisrequiredforcleavageoferbB4/HER4.JBiolChem2000Apr7;275(14):10379-87
