BiologicalActivity
Orallyeffectivevanilloidreceptor1(TRPV1receptor)antagonist.Inhibitsacid-andcapsaicin-inducedactivationofratTRPV1receptors(IC50valuesare6.0and35nMrespectively).Displaysanalgesicpropertiesinratmodelsofinflammatoryandneuropathicpain.CNSpenetrant.
CompoundLibraries
BCTCisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 372.89 |
| Formula | C20H25ClN4O |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 393514-24-4 |
| PubChemID | 9929425 |
| InChIKey | ROGUAPYLUCHQGK-UHFFFAOYSA-N |
| Smiles | ClC1=CC=CN=C1N2CCN(C(NC3=CC=C(C(C)(C)C)C=C3)=O)CC2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.29 | 100 | |
| ethanol | 14.92 | 40 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight372.89.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.68mL | 13.41mL | 26.82mL |
| 5mM | 0.54mL | 2.68mL | 5.36mL |
| 10mM | 0.27mL | 1.34mL | 2.68mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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