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Tocris/Bay 11-7085/1743/10/10 mg
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Tocris/Bay 11-7085/1743/10/10 mg
品牌 / 
Tocris
货号 / 
1743/10
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4000-520-616
Description:IrreversIBLeinhibitorofTNF-α-inducedIκBαphosphorylation
AlternativeNames:Bay11-7083
ChemicalName:(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

IrreversibleinhibitorofTNF-α-stimulatedIκBαphosphorylation(IC50~10μM);leadstodecreasedNF-κBandsubsequentdecreasedexpressionofadhesionmolecules.AlsoreversiblyactivatesMAPkinasesandstimulatesapoptosis.Anti-inflammatoryinvivo.

TechnicalData

M.Wt249.33
FormulaC13H15NO2S
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber196309-76-9
PubChemID5353432
InChIKeyVHKZGNPOHPFPER-ONNFQVAWSA-N
SmilesCC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO24.93100
ethanol24.93100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight249.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.01mL20.05mL40.11mL
5mM0.8mL4.01mL8.02mL
10mM0.4mL2.01mL4.01mL
50mM0.08mL0.4mL0.8mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet