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Description:IrreversIBLeinhibitorofTNF-α-inducedIκBαphosphorylation
AlternativeNames:Bay11-7083
ChemicalName:(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
IrreversibleinhibitorofTNF-α-stimulatedIκBαphosphorylation(IC50~10μM);leadstodecreasedNF-κBandsubsequentdecreasedexpressionofadhesionmolecules.AlsoreversiblyactivatesMAPkinasesandstimulatesapoptosis.Anti-inflammatoryinvivo.
TechnicalData
| M.Wt | 249.33 |
| Formula | C13H15NO2S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 196309-76-9 |
| PubChemID | 5353432 |
| InChIKey | VHKZGNPOHPFPER-ONNFQVAWSA-N |
| Smiles | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.93 | 100 | |
| ethanol | 24.93 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight249.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.01mL | 20.05mL | 40.11mL |
| 5mM | 0.8mL | 4.01mL | 8.02mL |
| 10mM | 0.4mL | 2.01mL | 4.01mL |
| 50mM | 0.08mL | 0.4mL | 0.8mL |
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ProductDatasheets
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