BiologicalActivity
Cell-permeablecalmodulin(CaM)antagonistthatbindstotheEF-hand/Ca2+-bindingsite.CALP2hasbeendemonstratedtoinhibitCaM-dependantphosphodiesteraseactivityandincreaseintracellularCa2+concentrationsbymodulatingCa2+-channelactivity.CALP2hasalsobeenshowntobeapotentactivatorofalveolarmacrophages.
TechnicalData
| M.Wt | 1357.72 |
| Formula | C68H104N14O13S |
| Sequence | VKFGVGFKVMVF |
| Storage | Desiccateat-20°C |
| CASNumber | 261969-04-4 |
| PubChemID | 90471211 |
| InChIKey | ODWOEJYNFFTQOH-IVGXUUFVSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1357.72.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.74mL | 3.68mL | 7.37mL |
| 5mM | 0.15mL | 0.74mL | 1.47mL |
| 10mM | 0.07mL | 0.37mL | 0.74mL |
| 50mM | 0.01mL | 0.07mL | 0.15mL |
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