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Description:InhibitsTCF-dependenttranscription;lowersβ-cateninlevels
ChemicalName:1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanonehydrobromide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
InhibitorofTCF-dependenttranscription.BlocksBIO-inducedβ-cateninstABIlization;reducesnuclearandcytosolicβ-cateninlevelsinmouseL-cells.InhibitsgrowthandreducesTCF-dependenttranscriptioninSW480coloncarcinomacells.
CompoundLibraries
CCT031374hydrobromideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 434.33 |
Formula | C23H19N3O.HBr |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 1219184-91-4 |
PubChemID | 18554738 |
InChIKey | MPILENOYNNNGKO-UHFFFAOYSA-N |
Smiles | O=C(C4=CC=C(C5=CC=CC=C5)C=C4)CN1C3=C(C=CC=C3)N2C1=NCC2.Br |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 21.72 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight434.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.3mL | 11.51mL | 23.02mL |
5mM | 0.46mL | 2.3mL | 4.6mL |
10mM | 0.23mL | 1.15mL | 2.3mL |
50mM | 0.05mL | 0.23mL | 0.46mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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