BiologicalActivity
InhibitorofWnt/β-cateninsignalinganddualantagoNISTofPPARγ/δactivity.Suppressesβ-catenin/Tcf-mediatedtranscription;inhibitsβ-cateninandGRIP1recruitmenttoPPARγandδ.Exhibitsantiproliferativeeffectsintransformedcolon,lungandlivercancercelllines.
CompoundLibraries
FH535isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 361.2 |
| Formula | C13H10Cl2N2O4S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 108409-83-2 |
| PubChemID | 3463933 |
| InChIKey | AXNUEXXEQGQWPA-UHFFFAOYSA-N |
| Smiles | ClC1=CC(S(NC2=C(C)C=C([N+]([O-])=O)C=C2)(=O)=O)=C(Cl)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.09 | 75 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight361.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.77mL | 13.84mL | 27.69mL |
| 5mM | 0.55mL | 2.77mL | 5.54mL |
| 10mM | 0.28mL | 1.38mL | 2.77mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
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