BiologicalActivity
Anticonvulsantandantiepileptic;alsousedtotreatneuropathicpain.Bindswithhighaffinityandselectivitytotheα2δsubunitofvoltage-sensitiveCa2+channelsandmodulatestheiractivity.Displaysanxiolytic-likeactivityinethologicalandconflictmodelsofanxiety.AnalogofGABA(Cat.No.0344).
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 159.23 |
| Formula | C8H17NO2 |
| Storage | StoreatRT |
| CASNumber | 148553-50-8 |
| PubChemID | 5486971 |
| InChIKey | AYXYPKUFHZROOJ-ZETCQYMHSA-N |
| Smiles | CC(C)C[C@H](CN)CC(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.92 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight159.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 6.28mL | 31.4mL | 62.8mL |
| 5mM | 1.26mL | 6.28mL | 12.56mL |
| 10mM | 0.63mL | 3.14mL | 6.28mL |
| 50mM | 0.13mL | 0.63mL | 1.26mL |
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