BiologicalActivity
VeryhighaffinityClC-2blocker(apparentKD~50pM).SlowsClC-2activationandinhibitsslow-gatingbutdoesnotinhibitopenClC-2channels.SelectiveforClC-2overotherClCfamilymembers(ClC-0,ClC-1,ClC-3andClC-4),CFTR,GABAC,CaCCandKV1.2.
TechnicalData
| M.Wt | 3192.54 |
| Formula | C125H199N39O47S6 |
| Sequence | VSCEDCPDHCSTQKARAKCDNDKCVCEPI (Modifications:Disulfidebridge:3-19,6-24,10-26) |
| Storage | Storeat-20°C |
| CASNumber | 194665-85-5 |
| PubChemID | 90488986 |
| InChIKey | NDCNPIYRYDSDEM-TZZHORBYSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)[C@@H](C)O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight3192.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.31mL | 1.57mL | 3.13mL |
| 5mM | 0.06mL | 0.31mL | 0.63mL |
| 10mM | 0.03mL | 0.16mL | 0.31mL |
| 50mM | 0.01mL | 0.03mL | 0.06mL |
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