BiologicalActivity
InhibitorofTCF/β-catenin-mediatedtranscription.Selectivelyinhibitsβ-catenin/CBPinteraction;displaysnoeffectonβ-catenin/p300interaction.Exhibitsgrowthinhibitoryeffectsincoloncarcinomacelllines(SW480andHCT-116cells);alsodisplaysefficacyinMinmouseandnudemouseSW620xenograftmodels.
TechnicalData
| M.Wt | 548.63 |
| Formula | C33H32N4O4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 847591-62-2 |
| PubChemID | 11238147 |
| InChIKey | HQWTUOLCGKIECB-XZWHSSHBSA-N |
| Smiles | O=C1CCN(C(NCC5=CC=CC=C5)=O)[C@]2([H])N1[C@@H](CC6=CC=C(O)C=C6)C(N(CC3=C(C=CC=C4)C4=CC=C3)C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.86 | 100 | |
| ethanol | 27.43 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight548.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.82mL | 9.11mL | 18.23mL |
| 5mM | 0.36mL | 1.82mL | 3.65mL |
| 10mM | 0.18mL | 0.91mL | 1.82mL |
| 50mM | 0.04mL | 0.18mL | 0.36mL |
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