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Tocris/JW 74/5653/50/50 mg

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Tocris

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5653/50

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4000-520-616

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Description:Wntpathwayinhibitor

ChemicalName:4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxADIazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofcanonicalWntsignaling(IC₅₀=790nM).Targetstheβ-catenindestructioncomplex(GSK-3beta/AXIN/APC).IncreasesAXIN2anddecreasesactiveβ-cateninlevelsincolorectalcancer(CRC)cells.AlsoarrestscellcycleinG₁andinhibitsproliferationofCRCcellsinvitro.Inhibitstumorgrowthandformationinmousemodels.

CompoundLibraries

JW74isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	456.52
Formula	C₂₄H₂₀N₆O₂S
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	863405-60-1
PubChemID	16013152
InChIKey	KRIKILRRJCIWNB-UHFFFAOYSA-N
Smiles	COC1=CC=C(N2C(SCC3=NC(C4=CC=C(C)C=C4)=NO3)=NN=C2C5=CC=NC=C5)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	45.65	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight456.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.19mL	10.95mL	21.9mL
5mM	0.44mL	2.19mL	4.38mL
10mM	0.22mL	1.1mL	2.19mL
50mM	0.04mL	0.22mL	0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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