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Tocris/KM 11060/3143/10/10 mg

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Tocris

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3143/10

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Description:CorrectsF508del-CFTRtrafficking

ChemicalName:7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

CorrectsF508del-CFTRtrafficking;increasestheamountoffunctionalCFTRattheplasmamembrane(~75%).ShowntoinhibitPDE5activity.

TechnicalData

M.Wt	422.33
Formula	C₁₉H₁₇Cl₂N₃O₂S
Storage	StoreatRT
Purity	≥98%(HPLC)
CASNumber	774549-97-2
PubChemID	1241327
InChIKey	GIEHIZKCIZLXLF-UHFFFAOYSA-N
Smiles	ClC(C=C4)=CC=C4S(N(CC3)CCN3C1=CC=NC2=C1C=CC(Cl)=C2)(=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	42.23	100
	ethanol	4.22	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight422.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.37mL	11.84mL	23.68mL
5mM	0.47mL	2.37mL	4.74mL
10mM	0.24mL	1.18mL	2.37mL
50mM	0.05mL	0.24mL	0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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PreparingStockSolutions

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