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Tocris/Erastin/5449/10/10 mg

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Tocris

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5449/10

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4000-520-616

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Description:MitochondriaVDACmodulator;alsoFerroptosisactivator

ChemicalName:2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Antitumoragent;selectiveforcellsexpressingoncogenicRAS.AlsoFerroptosisactivator;inducesoxidative,non-apoptoticcelldeathintumorsbymodulatingmitochondrialvoltage-dependentanionchannels(VDAC).Cellpermeable.

TechnicalData

M.Wt	547.04
Formula	C₃₀H₃₁ClN₄O₄
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	571203-78-6
PubChemID	11214940
InChIKey	BKQFRNYHFIQEKN-UHFFFAOYSA-N
Smiles	O=C2C1=CC=CC=C1N=C(C(N4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)C)N2C3=C(OCC)C=CC=C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	10.94	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight547.04.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.83mL	9.14mL	18.28mL
5mM	0.37mL	1.83mL	3.66mL
10mM	0.18mL	0.91mL	1.83mL
50mM	0.04mL	0.18mL	0.37mL

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CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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PreparingStockSolutions

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