BiologicalActivity
Potentandselective,competitivevanilloidTRPV1receptorantagonist(IC50=17nM).Inhibitscapsaicin-,proton-,heat-andendogenousligand-inducedactivationofhumanandratrecombinantTRPV1receptors.Displaysantihyperalgesicpropertiesinaratmodelofinflammatorypain.
CompoundLibraries
AMG9810isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 337.42 |
| Formula | C21H23NO3 |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 545395-94-6 |
| PubChemID | 680502 |
| InChIKey | GZTFUVZVLYUPRG-IZZDOVSWSA-N |
| Smiles | CC(C)(C)C1=CC=C(C=C1)C=CC(=O)NC1=CC=C2OCCOC2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.87 | 50 | |
| ethanol | 33.74 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight337.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.96mL | 14.82mL | 29.64mL |
| 5mM | 0.59mL | 2.96mL | 5.93mL |
| 10mM | 0.3mL | 1.48mL | 2.96mL |
| 50mM | 0.06mL | 0.3mL | 0.59mL |
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