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Tocris/AP 18/3296/10/10 mg

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Tocris

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3296/10

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Description:ReversIBLeTRPA1channelblocker

ChemicalName:4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

ReversibleTRPA1channelblocker(IC₅₀valuesare3.1and4.5μMathumanandmouseTRPA1respectively).Blockscinnameldehyde-inducedbutnotcapsaicin-inducednociceptionandreversesmechanicalhyperalgesiainvivo.AlsoblocksTRPA1poredilation(IC₅₀=10.3μMfortheinhibitionofYo-Prouptake).

CompoundLibraries

AP18isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	209.67
Formula	C₁₁H₁₂ClNO
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	55224-94-7
PubChemID	9584673
InChIKey	MHTJEUOFLVQMCL-NJHPPEEMSA-N
Smiles	ClC1=CC=C(/C=C(C)/C(C)=N/O)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	20.97	100
	ethanol	20.97	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight209.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	4.77mL	23.85mL	47.69mL
5mM	0.95mL	4.77mL	9.54mL
10mM	0.48mL	2.38mL	4.77mL
50mM	0.1mL	0.48mL	0.95mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

CompoundLibraries

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PreparingStockSolutions

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