进口Tocris现货 Tocris小分子,Tocris/APETx2/4804/100U/100 ug,信号通路,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/APETx2/4804/100U/100 ug

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Tocris

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4804/100U

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4000-520-616

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Description:ASIC3channelblocker

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Acid-sensingionchannel3(ASIC3)channelblocker(IC₅₀valuesare63and175nMforhomomericratandhumanASIC3channels).AlsoinhibitsNa_V1.8andNa_V1.2channels(IC₅₀valuesare55and114nMrespectively).Demonstratesanalgesicpropertiesagainstacid-inducedandinflammatorypain.

TechnicalData

M.Wt	4561.06
Formula	C₁₉₆H₂₈₀N₅₄O₆₁S₆
Sequence	GTACSCGNSKGIYWFYRPSCPTDRGYTGSCRYFLGTCCTPAD (Modifications:Disulfidebridgebetween4-37,6-30,20-38)
Storage	Storeat-20°C
CASNumber	713544-47-9
PubChemID	90488973
InChIKey	HEHYILNFEUDIQC-UHFFFAOYSA-N
Smiles	[H]NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CSSC[C@H](NC2=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N3)[C@@H](C)O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

Solubility	Solubleto5mg/mlinwater

Solubility

Solubleto5mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight4561.06.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.22mL	1.1mL	2.19mL
5mM	0.04mL	0.22mL	0.44mL
10mM	0.02mL	0.11mL	0.22mL
50mM	0mL	0.02mL	0.04mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

MolarityCalculator

ReconstitutionCalculator

DilutionCalculator

ProductDatasheets