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Interactions between cells responsible for cell to cell adhesion also can communicate signals into the cellular interior, often involving interactions with cyt
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Activation of the MAPK kinase pathway has been identified as a mechanism that integrins use to regulate gene expression leading to cell shape changes during ce
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The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growth factor
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The HER4/erbB4 receptor tyrosine kinase is a member of the EGF1 receptor family. HER4 is a receptor for the neuregulins (NRGs), a family of growth and differen
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Cellulartransformationisaccompaniedbymanycellularchanges,includinguncontrolledproliferation,lossofthedifferentiatedcellmorphology,andinvasionoftheextracellularmatrix.Degradationoftheextracellularmatrixisakeycomponentoftumorcellinvasionintosurroundingtissu
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As tissues grow they require angiogenesis to occur if they are to be supplied with blood vessels and survive. Factors that inhibit angiogenesis might act as ca
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The mammalian calpain gene family curently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. ( An exce
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The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to DNA stimu
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