IGF-1R,thetype1receptorforinsulin-likegrowthfactor,mediatescellsurvivalandgrowthinresponsetoitsligandsIGF-1andIGF-2.Thistyrosinekinasereceptoriswidelyexpressedinmanycelltypesandisakeymediatorofgrowth.OverexpressionoractivationofIGF-1Rmaybeinvolvedintheproliferationoftransformedcells,makinginhibitionofIGF-1Rsignalingastrategyforthedevelopmentofcancerdrugs.IGF-1RactivatesthreesignalingpathwaysthatconvergetophosphorylateBADproteinandblockapoptosis.ThefirstpathwayactivatedbyIGF-1RstimulatesPI3-kinaseandtheAKTpathwaytophosphorylateBADandblockapoptosis.AsecondpathwayactivatedbyIGF-1Rinvolvesrasmediatedactivationofthemapkinasepathwaytoblockapoptosis.AthirdpathwayinvolvesinteractionofrafwithmitochondriainresponsetoIGF-1Ractivation.TheconvergenceofthesepathwaystoblockapoptosismayenhancetheIGF-1Rresponse. Contributor: REFERENCES:
