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Bpsbioscience/Z-WEHD-FMK/27672-3/25 mg
2025-05-12
MW: 76.8 Da CAS Registry #: 210345-00-9 Formula: C37H42FN7O10 Target: caspase-5 Background:Since caspase-14 also recognizes this WEHD substrate, this inhibitor may also show inhibition of caspase-14 activity. Description:A cell permeable, synthetic peptide that irreversibly inhibits certain caspases. It is selective for caspase-5, but also shows some inhibition of caspase-1 and cathepsin B (IC50 = 6 µM). Biological Activity: We recommend using 2-10 µM for inhibiting caspase activity in cell culture. The optimal dose may vary for different cells and culture conditions. Solubility: Soluble in DMSO Storage / Stability:
Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.
Reference(s): 1. Heuer, D., et al. Nature, 457, 20092. Kamada, S., Fet al. (1997) Cell Death Diff. 4, 473-478.3. Park, K., et al. Biochem Biophys Res Commun. 2006 Sep 8;347(4):941-8. Notes: The inhibitor is designed as a methyl ester to facilitate cell permeability. If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups. Amino Acid Sequence: Z-Trp-Glu(OMe)-His-Asp(OMe)-FMK Scientific Category: Apoptosis Inhibitor Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.本文链接： https://www.ebiomall.cn/b166-bps/info-1517619014.html
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