FabGennix/MC4 Receptor Antibody/MC4R-401AP/
Product | MC4 Receptor Antibody |
Description | Affinity Purified Melanocortin receptor 4 Antibody |
Verified Applications | ELISA, IHC, IP, WB |
Host | Rabbit |
Species Cross Reactivity | Human, Mouse, Rat |
Immunogen | Synthetic peptide taken within amino acid region 10-60 on human MC4R protein. |
Accession # | NCBI: NP_005903.2 |
Physical Properties | |
Quantity | 100 µg |
Volume | 200 µl |
Concentration | 0.55-0.75 µg/µl in antibody stabilization buffer |
Form | Affinity Purified |
Clonality | Polyclonal |
Storage | -20⁰C for long term storage |
Application Protocol | |
DB | 1:10,000 |
ELISA | 1:10,000 |
| Immunohistochemistry | 1:100 |
| Immunoprecipitation | 1:200 |
Western Blot | 1:500 |
Protein | |
Uniprot # | P32245 |
Overview | Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). |
Molecular Function | Melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, neuropeptide binding, ubiquitin protein ligase binding |
Subcellular Location | cell membrane, multi-pass membrane protein, membrane raft. (Note: Localizes to membrane rafts but is also loated in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts). |
Expression | Brain, placental, and gut tissues. |
Alternative Nomenclature | MC4 R antibody Melanocortin receptor 4 antibody MGC126851 antibody MGC138197 antibody |
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