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Signosis/Lysosomal Stress TF Activation Profiling Plate Array/FA-1012/1 Ea
2025-05-06
Description:
The lysosome plays a key role in cellular homeostasis by controlling both cellular clearance and energy production to respond to environmental cues. It is well known that transcription factor EB (TFEB) and mTOR complex 1 (mTORC1) are master regulators of lysosomal biogenesis.Under starvation, cells initiate the process of autophagy and increase the capacity of the lysosome by the lysosome stress response. mTORC1 dissociates from the lysosome and becomes inactivated, leading to dephosphorylation of TFEB and autophagy. Dephosphorylated TFEB enters the nucleus, binds to the enhancer element CLEAR, and activates transcription of genes related to the lysosome as well as autophagy. The lysosome stress response is closely related to various diseases such as Huntington’s disease, liver disease and lysosomal storage diseases including Pompe disease. Recently, more TFs have been reported to be associated with lysosome stress, such as p53, FOXO1, PPAR, Stat3, NFkB, HIF, HSF and MITF.本文链接： https://www.ebiomall.cn/b327-signosis/info-1548304592.html
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