货号：	58003
抗体名：	ACSS2(Phospho-Ser659)磷酸化抗体
抗体英文名：	ACSS2(Phospho-Ser659)Antibody
靶点：	ACSS2(Phospho-Ser659)
浓度：	1mg/ml
应用范围：	WB
宿主：	兔
供应商：	南京赛博生物科技有限公司
抗原来源：	合成多肽
保质期：	1年
适应物种：	任，小鼠
克隆性：	否
保存条件：	-20度
规格：	50ul/100ul

Overcoming metabolic stress is a critical step in tumor growth. Acetyl coenzyme A (acetyl-CoA) generated from glucose and acetate uptake is important for his-tone acetylation and gene expression. However, how acetyl-CoA is produced under nutritional stress is un-clear. We demonstrate here that glucose deprivation results in AMP-activated protein kinase (AMPK)-medi-ated acetyl-CoA synthetase 2 (ACSS2) phosphoryla-tion at S659, which exposed the nuclear localization signal of ACSS2 for importin a5 binding and nuclear translocation. In the nucleus, ACSS2 binds to tran-scription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-CoA for histone H3 acetylation in these regions and pro-mote lysosomal biogenesis, autophagy, cell survival, and brain tumorigenesis. In addition, ACSS2 S659 phosphorylation positively correlates with AMPK ac-tivity in glioma specimens and grades of glioma malig-nancy. These results underscore the significance of nuclear ACSS2-mediated histone acetylation in main-taining cell homeostasis and tumor development. 温馨提示：不可用于临床治疗。