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Description

Glycoprotein 38 (gp38) is a transmembrane O-glycoprotein that maintains barrier function in high endothelial venules. In development, gp38 activates platelets to induce separation of lymphatic and blood vascular systems. Additionally, gp38 may exhibit carcinogenic/tumorigenic activity, as it promotes cell motility via PKA signaling and is used as a biomarker to detect various cancers.

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References

Herzog BH, Fu J, Wilson SJ, et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 3;502(7469):105-9. PMID: 23995678.

Krishnan H, Ochoa-Alvarez JA, Shen Y, et al. Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility. J Biol Chem. 2013 Apr 26;288(17):12215-21. PMID: 23530051.

Konishi S, Yasuchika K, Ishii T, et al. A transmembrane glycoprotein, gp38, is a novel marker for immature hepatic progenitor cells in fetal mouse livers. In Vitro Cell Dev Biol Anim. 2011 Jan;47(1):45-53. PMID: 21104040.

Uhrin P, Zaujec J, Breuss JM, et al. Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood. 2010 May 13;115(19):3997-4005. PMID: 20110424.