LKT/PLURISLN 1/P4782/5 mg
- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
PluriSin 1 is a pluripotent cell-specific inhibitor that induces endoplasmic reticular stress and apoptosis in pluripotent stem cells. This compound inhibits stearoyl-coA desaturase 1 (SCD1), preventing teratoma formation in tumorigenic undifferentiated cells. Plurisin1 prevents undifferentiated cells from developing into tumors when used to regenerate tissues such as the heart.
Product Info
91396-88-2 |
≥98% |
C12H11N3O |
213.24 |
N-Phenylisonicotinohydrazide |
NSC 14613 |
Shipping and Storage
-20°C |
Ambient |
Downloads
P4782 Info Sheet PDF |
References
Zhang L, Pan Y, Qin G, et al. Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Cell Cycle. 2014;13(5):762-71. PMID: 24394703.
Ben-David U, Gan QF, Golan-Lev T, et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell. 2013 Feb 7;12(2):167-79. PMID: 23318055.
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