Product overview

• NameZebularine
• Short descriptionDNA methyltransferase inhibitor. Induces cardiomyocyte differentiation in MSCs.
• Biological descriptionDNA methyltransferase inhibitor. Stabilises p53 in colorectal cancer cells and causes p53-dependent ER stress and autophagy. Also inhibits cytidine deaminase and influences embryonic stem cell differentiation. Shows anti-proliferative and anti-cancer actions.
• Alternative names1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one; 2-Pyrimidone-1-β-D-riboside; NSC 309132; Zeb
• Biological actionInhibitor
• Purity>99%
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Properties

• Chemical name1-β-D-Ribofuranosyl-2(1H)-pyrimidino ne
• Molecular Weight228.2
• Chemical structure
• Molecular FormulaC₉H₁₂N₂O₅
• CAS Number654065

Storing and Using Your Product

• Storage instructionsroom temperature (desiccate)
• Solubility overviewsoluble in water (100mM) or DMSO (100mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Zebularine

• Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress.

  Yang PM et al (2013)Sci Rep 3 : 3219 PubMedID: 24225777

• Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment.

  Horrillo A et al (2013)Cell Death Dis 4 : e570. PubMedID: 23559004

• Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2-deoxycytidine by human cytidine deaminase.

  Lalibertã? J et al (1992)Cancer Chemother Pharmacol 30(1) : 7-11. PubMedID: 1375134