新闻动态
ubpbio/Torin-1/F6101/25 mg
2025-06-22
Torin 1-is a cell permeable highly potent, selective and ATP-competitive mTOR inhibitor of the mammalian target of rapamycin (mTOR) kinase. Torin-1 exhibits over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, as well as 450 other protein kinases. Torin-1 has been found to impair cell growth and proliferation through a mechanism involving mTORC1 inhibition other than mTORC2 inhibition, in which the rapamycin-resistant functions of mTORC1 is suppressed.
Additional Information
| Torin-1 |
| 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| F6101 |
| 25 mg |
| 607.62 Da |
| N/A |
| Synthetic |
| Powder |
| N/A |
| >99% by HPLC and NMR |
| Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light |
| PDF Datasheet |
| N/A |
| N/A |
| Room temperature shipping |
| 1. Guertin DA, et al. (2009) Sci.Signal. 2(67):pe242. Thoreen CC, et al. (2009) J.Biol.Chem. 284(12):8023-323. Liu Q, et al. (2010) J.Med.Chem. 53(19):7146-55 |
Details
Torin 1-is a cell permeable highly potent, selective and ATP-competitive mTOR inhibitor of the mammalian target of rapamycin (mTOR) kinase. Torin-1 exhibits over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, as well as 450 other protein kinases. Torin-1 has been found to impair cell growth and proliferation through a mechanism involving mTORC1 inhibition other than mTORC2 inhibition, in which the rapamycin-resistant functions of mTORC1 is suppressed..How to useTorin-1 was used at 2-5,000 nM in cell-balsed in vitro assays.
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