| Cat-Nr. | 102-P23 |
| Size | 100 µg |
| Price | 235 € |
| Category | Polyclonal Antibody |
| Clone Nr. | Rabbit IgG |
| Species Reactivity | Human |
| Formulation | lyophilized from PBS |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Produced from sera of rabbits immunized with highly pure recombinant Human B7-H1/PD-L1 Fc. Anti-Human B7-H1-specific antibody was purified by affinity chromatography employing an immobilized Human B7-H1/PD-L1 Fc matrix. |
| Antigen | Recombinant human B7-H1/PD-L1 Fc |
| Application | ELISA, WB |
| Synonyms | Programmed Death Ligand 1, Programmed cell death 1 Ligand 1 (PDCD1L1), PD-1, B7-H1 (B7 homolog 1), CD274, SLEB2, SLE1 |
| Description | Human B7 homolog 1 (B7H1), also called programmed death ligand 1 (PDL1) and programmed cell death 1 ligand 1 (PDCD1L1), is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. Other family members include B71, B72, B7H2, PDL2 and B7H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, their extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. Among the family members, they share about 20 25% amino acid identity. Human and mouse B7H1 share approximately 70% amino acid sequence identity. B7H1 has been identified as one of two ligands for programmed death1 (PD1), a member of the CD28 family of immunoreceptors. The B7H1 gene encodes a 290 amino acid (aa) type I membrane precursor protein with a putative 18 aa signal peptide, a 221 aa extracellular domain, a 21 aa transmembrane region, and a 31 aa cytoplasmic domain. Human B7H1 is constitutively expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. B7H1 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. B7H1 expression is also induced in dendritic cells and keratinocytes after IFNγ stimulation. Interaction of B7H1 with PD1 results in inhibition of TCR-mediated proliferation and cytokine production. The B7H1: PD1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance. |
| Uniprot ID | Q9NZQ7 |
| Protein RefSeq | NP_054862.1 |
| mRNA RefSeq | NM_014143.3 |
ebiomall.com
>
>
>
>
>
>
>
>
>
>
>
>
介绍了日本常用的药用辅料的安全性数据,类似美国的IIG,有较大参考价值,
举例
和名 ポリオキシエチレン(105)ポリオキシプロピレン(5)グリコール
英文名 Polyoxyethylene(105)Polyoxypropylene(5)Glycol
CAS9003-11-6
別名 PEP-101(110672)
収載公定書 薬添規(2003)
用途 界面活性剤,可塑剤,可溶(化)剤,コーティング剤,賦形剤,分散剤,崩壊剤,糖衣剤
■最大使用量
経口投与 400mg
以下については該当文献なし.
■単回投与毒性
■反復投与毒性
■遺伝毒性
■癌原性
■生殖発生毒性
■局所刺激性
■その他の毒性
■ヒトにおける知見
■引用文献
下面是连接,版头有搜索入口,支持日文检索
http://www.jpec.gr.jp/detail=normal&date=safetydata/data.html
2014年10月21日08:55:05来源:中国青年报
“在我国,90%左右的人认为食品安全问题是食品添加剂所造成的,但很多人把非法添加物误认为是食品添加剂。”在近日召开的中国食品安全年会上,中国工程院院士孙宝国解释了食品添加剂与非法添加物的不同。
他指出,食品添加剂的使用有着6点需要,首先是为了改善食品品质。以婴幼儿配方奶粉为例,许多婴幼儿奶粉中正是因为添加了符合标准的食品添加剂,才能最大程度地接近母乳成分。
其次,使用食品添加剂是食品防腐的客观需要。“很多消费者对防腐剂表示反感,但如果食品中没有防腐剂,那么有害的微生物就会迅速繁殖,而有害微生物污染恰恰是造成食品安全问题的第一大杀手。”孙宝国强调。
除此之外,他还指出,食品添加剂可以起到让食品保鲜、改善食品色香味、满足食品加工工艺等需求。“可乐里面一定含有咖啡因,因为没有咖啡因成分的话,就不可能称之为可乐。”孙宝国表示,从毒理学角度看,不少食品添加剂的确有毒,如卤水,但食品添加剂本身有毒与添加了食品添加剂的食品有毒绝对是两回事,主要区别在于食品添加剂的使用量。
“食品添加剂只要合法使用都是安全的,不会对人体健康造成危害,因此,一定要监管好食品添加剂的使用,违法使用,超量、超范围使用都有可能带来风险”。孙宝国说。
国家食品安全风险评估中心首席科学家吴永宁也指出,当前食品安全控制的应该是风险,而不是危害。“我们要规范好什么样的食品添加剂能用,以及使用剂量和使用范围。如果在规范之外,就是非法添加。三聚氰胺、苏丹红这些都是非法添加物,我们不能把非法添加物与食品添加剂进行混淆。”
1、血清:大部分人提及的Hyclone和Gibco,现在很多人对其血清的来源及目前市面上流行的真假好坏有怀疑,有人买到说好,有人说像是假的;也有人用国产的胎牛血清培养的,多提及兰州民海和四季青的,并且对兰州民海似乎支持者较多。对血清的选择还想说,不同厂家不同批次的血清都不同保证成分完全一致,对于使用者而言,可以从外观、培养方面了解血清的质量。
2、内皮生长因子:养内皮细胞都需加入生长因子,ECGS和ECGF用的较多,含量ECGS0.03-0.05mg/ml或ECGF50μg/ml,品牌提的最多的是Sigma的,但是Sigma的真心贵啊,另有些人提的最多的是罗氏,较便宜,75mg才2200RMB左右,性价比应该是比较高的,本人准备入手。
3、肝素:肝素在内皮细胞培养中的作用是抑制其他杂细胞的生长,尤其是平滑肌细胞的生长,使内皮细胞成为生长优势群,浓度不定,有几种说法:查阅书,15μg/ml;美国ATCC说明书,0.1mg/ml;另有50U/ml,肝素买的话大部分人也都推荐Sigma。
急求日本《医药品添加物事项》中有关“十六醇”的资料,请各位大神帮帮忙

