
Overview:
High temperature requirement protein A2 (HTRA2) is a serine protease that normally resides in mitochondrial membranes and plays a key role in the apoptosis pathways in different pathological conditions including myocardial ischemia/reperfusion injury. Heart ischemia /reperfusion induced HTRA2 translocation from the mitochondria to the cytosol promotes cardiomyocyte apoptosis via a protease activity-dependent and caspase-mediated pathway.
Gene Aliases:
OMI; PARK13; PRSS25
Genbank Number:
NM_013247
References:
1. Suzuki Y, et al: Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death Differ 11:208–216. 20042. Bhuiyan MS, et al: Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury. Cardio-vasc Ther. 26(3):224-32. 2008
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一抗的英语是 resistance No.1,二抗resistance No.2.
想通过亲和层析来纯化抗血小板特异性抗体(抗GPIIb/IIIa抗体和抗GPIbα抗体),能否做到呢?谢谢!

